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Chronicling America: Historic American Newspapers: 172 Years Ago: "The Raven," New-York Daily Tribune, Feb. 4, 1845

by @ Chronicling America: Historic American Newspapers

First published in late January 1845, “The Raven” by Edgar A. Poe quickly caught the attention of readers far and wide with its dark and gothic imagery. It soon appeared in numerous newspapers and magazines across the country including the Feb. 4, 1845 issue of the New-York Daily Tribune (New York, NY). "Once upon a midnight dreary..."  Read more about it and follow us on Twitter @librarycongress #ChronAm!

Chronicling America: Historic American Newspapers: 100 Years Ago: Peace in the Great War? Dec. 12 and 13, 1916

by @ Chronicling America: Historic American Newspapers

In mid-December 1916, Germany suddenly and unexpectedly proposed peace to the Allied nations of Europe involved in “the Great War.” Newspapers across America, still neutral in the conflict, announced the offer with surprise and glaring headlines. From the optimistic “The Dawn of Peace” (Bryan Daily Eagle and Pilot; Bryan, TX) and “End of World-Wide Conflict Near” (Bemidji Daily Pioneer; Bemidji, MN) to the dismay of Britain’s immediate response “England Receives Proposal Coldly” (New York Tribune; New York, NY) and “Peace Move Not Taken Seriously” (The Daily Gate City and Constitution-Democrat; Keokuk, IA),  America watched the war from afar with growing trepidation and debate…. Read more about it and follow us on Twitter @librarycongress #ChronAm!

 

Chronicling America: Historic American Newspapers: 148 Years Ago: “Phenomena of a Total Eclipse,” The Evening Telegraph, August 4, 1869

by @ Chronicling America: Historic American Newspapers

What did we know about the how’s and why’s of a total eclipse of the sun in 1869? Having experienced a total eclipse in North America just a few years prior in 1860, newspaper readers of 1869 were eager for information. The Evening Telegraph (Philadelphia, PA) presented that and more just before the August 7 event, providing a combination of science, story and conjecture to describe the phenomena, declaring “No approach to totality can give the slightest conception of the effect produced the instant that the last ray of light is extinguished.” On Monday, August 21, 2017 millions across America will make their own observations of this rare occurrence. Read more about it and follow us on Twitter @librarycongress #ChronAm #Eclipse2017!

Chronicling America: Historic American Newspapers: 125 Years Ago: “Whitman is Dead,” The Wilmington Daily Republican, March 28, 1892

by @ Chronicling America: Historic American Newspapers

Known as “the Good Gray Poet,” Walt Whitman, author of Leaves of Grass and other poems, died peacefully in March 1892 in Camden, NJ, after a long illness.  With a sorrowful tone, the Wilmington Daily Republican (Wilmington, DE) provided details along with reflections on his literary accomplishments and critics. “His critics ‘cut him up,’” according to the paper… Read more about it and follow us on Twitter @librarycongress #ChronAm!

Give Google Contributor a try

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

Recently I’ve seen several interesting conversations about ad blocking, and I wanted to remind people about a great offering called Google Contributor. With Google Contributor, you contribute a certain amount of money each month. That subscription means that you see fewer ads on the web, and you support the sites that you visit with your […]

Chronicling America: Historic American Newspapers: 95 Years Ago : "Get Out the Rabbit's Foot," The Morning Tulsa Daily World, October 13, 1922

by @ Chronicling America: Historic American Newspapers

Is it your lucky or unlucky day? For some Friday the 13th just a date on the calendar. But if you're superstitious, you might want to "put that rabbit's foot in your pocket 'till the evenin sun goes down" or travel the "straight and narrow, unless it takes you underneath a ladder."  Check out this article for more Friday the 13th suggestions and don't forget to follow us on Twitter @libraryofcongress #ChronAm! 

Chronicling America: Historic American Newspapers: 144 Years Ago: “Susan B. Anthony and Other Women Vote in Rochester,” Evening Star, November 5, 1872

by @ Chronicling America: Historic American Newspapers

Although women’s right to vote would not be assured until 1920, in November 1872 Susan B. Anthony, along with others, “presented herself to the eighth ward [Rochester, NY] and insisted on being registered…” to vote in the U.S. presidential election, according to the Evening Star (Washington, DC). Ten days later she was arrested and eventually fined. Read more about it and follow us on Twitter @librarycongress #ChronAm!

Click here for more information.

Chronicling America: Historic American Newspapers: Walt Whitman, "Life and Adventures of Jack Engle," and “Pride in the Library”

by @ Chronicling America: Historic American Newspapers

The famous and gay poet Walt Whitman often wrote stories for newspapers. His recently rediscovered serial novel, “Life and Adventures of Jack Engle,” a purported first-person autobiography, appeared anonymously in the Sunday Dispatch (New York , NY), March 14 through April 18, 1852. A front page ad in the New-York Daily Tribune of March 13, 1852 promised “A RICH REVELATION.” Whitman’s sensational tale of a poor orphan’s true heritage slipped into obscurity until 2016, when researcher Zachary Turpin connected the Whitman-esque style of the ad and the name “Jack Engle” to an 1852 Whitman notebook in the Library of Congress' Manuscript Division. Whitman had jotted down plot lines, characters, and scenes he used in the story. The only full set of newspaper issues in which Whitman’s “lost” novel was originally printed is now available digitally in Chronicling America and this weekend (June 8-10), the originals are on display at the Library’s “Pride in the Library” pop-up exhibit. In addition to newspapers, this exhibition features a range of items from the Library’s extensive LGBTQ+ collections…. Read more about it, learn more about Walt Whitman through newspapers, and follow us on Twitter @librarycongress #ChronAm and @Events_LOC #LCPride!

 

Chronicling America: Historic American Newspapers: NEH Announces Guidelines for 2017 NDNP Awards - Application Deadline: January 12, 2017

by @ Chronicling America: Historic American Newspapers

The National Digital Newspaper Program (NDNP) grant guidelines for 2017 are now available at http://www.neh.gov/grants/preservation/national-digital-newspaper-program. The deadline for submitting proposals is January 12, 2017.

Program awardees participate in the creation of a national, digital resource of historically-significant public domain newspapers published in U.S. states and territories. This program is jointly sponsored by the National Endowment for the Humanities (NEH) and the Library of Congress (LC). Each award supports a 2-year project to digitally convert 100,000 newspaper pages from that state's collections for contribution to the Chronicling America website, maintained by the LC. For a list of current participants, see http://www.loc.gov/ndnp/awards/.

For more program information, please visit the NEH's program page at http://www.neh.gov/grants/preservation/national-digital-newspaper-program or for technical information, visit the LC site at http://www.loc.gov/ndnp/ .... Read more about it and follow us on Twitter @librarycongress #ChronAm!

See NEH 2017 Grant Application Guidelines

Chronicling America: Historic American Newspapers: 100 Years Ago : “U.S. Is In It At Last,” The Tacoma Times, April 6, 1917

by @ Chronicling America: Historic American Newspapers

After more than two years of remaining neutral in the conflict happening 'over there,' President Woodrow Wilson issues a proclamation on April 6, 1917 to the people of the country declaring a state of war exists between the United States and the Imperial Government of Germany. The  first act of war was to seize all 91 German ships in American waters, weighing a total tonnage of 594,696, the news reports.... Read more about it and explore our Recommended Topics by Subject to learn about more about what newspapers reported during World War I! Follow us on Twitter @librarycongress #ChronAm!

 

Chronicling America: Historic American Newspapers: "Mr. Skygack, from Mars" and the “Library of Awesome”

by @ Chronicling America: Historic American Newspapers

“Some years ago a gentle, inoffensive stranger landed on this terrestrial sphere with no luggage but a book….This was Mr. Skygack from Mars,” wrote Fred Schaefer, author of the comic “Mr. Skygack, from Mars” in the Day Book (Chicago, IL) in 1912.  This early comic strip first began appearing in newspapers associated with the Scripps publishing conglomerate in 1907. Explore Mr. Skygack’s wry observations of human behavior through our Recommended Topics page and, this week (June 14-17), join us at LC for our “Library of Awesome” pop-up exhibit highlighting gems from our extensive collection of comic books. This exhibition features famous comic-book issues, drawings, original comic strips and related items…. Read more about it, learn more about comics in historic newspapers, and follow us on Twitter @librarycongress #ChronAm and @Events_LOC #LCcomics!

Next 30 day challenge: social media/news cleanse

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

For January 2015, I tried to declutter around the house for 15 minutes a day. We now have a couple rooms that are much cleaner, and I gave away a bunch of magazines. For February 2015, my 30 day challenge was to go on daily 15 minute walks with my wife. That was nice. Lately […]

Ciliopathy-associated protein CEP290 modifies the severity of retinal degeneration due to loss of RPGR | Human Molecular Genetics | Oxford Academic

Ciliopathy-associated protein CEP290 modifies the severity of retinal degeneration due to loss of RPGR | Human Molecular Genetics | Oxford Academic


OUP Academic

Mutations in RPGR (retinitis pigmentosa GTPase regulator) are the most common cause of X-linked RP, a severe blindness disorder. RPGR mutations result in clinically variable disease with early- to late-onset phenotypic presentation. Molecular mechanisms underlying such heterogeneity are unclear. Here we show that phenotypic expression of Rpgr-loss in mice is influenced genetically by the loss of Cep290, a human ciliopathy gene. We found that Rpgrko/Y mice with a heterozygous hypomorphic allele of Cep290 (Cep290rd16/+) but not of a heterozygous null allele of Cep290 (Cep290null/+) or of other ciliopathy genes, Rpgrip1, Nphp1, Nphp4 and Nphp5, exhibit relatively early onset (by 3 months of age) retinal degeneration and dysfunction when compared with the onset at ∼7 months of age in the Rpgrko/Y mice. We also observed disorganized photoreceptor outer-segment morphology and defective trafficking of opsins in the Rpgrko/Y::Cep290rd16/+ mice. Together with a physical interaction between RPGR and the C-terminal domain of CEP290, our data suggest that RPGR and CEP290 genetically interact and highlight the involvement of hypomorphic alleles of genes as potential modifiers of heterogeneous retinal ciliopathies.

Staying with the US Digital Service

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

A few months ago, I took a leave of absence from Google to do a stint with the US Digital Service. A lot of people know about the US Digital Service because they helped rescue the healthcare.gov website. But you might not realize that the US Digital Service has helped veterans get their health benefits, […]

Chronicling America: Historic American Newspapers: Help Us Understand How You Use Chronicling America!

by @ Chronicling America: Historic American Newspapers

We’re asking for your help to understand how you, the users, work with our online newspapers! The Library of Congress is investigating new approaches to providing access to the historic newspapers available from the Chronicling America Web site. We’re looking at adding new features and updating others, as well as integrating the historic newspapers with related materials from the Library’s overall collections like maps, photographs, handwritten letters and more!

If you use historic digitized newspapers in Chronicling America, please take a few minutes and answer our simple anonymous survey (only 6 quick questions!) describing a few key features we’re thinking about.

Please respond by COB Wednesday, May 17.

We appreciate your feedback and thank you!

 

What would you do if you were CEO of Google?

What would you do if you were CEO of Google?


Matt Cutts: Gadgets, Google, and SEO

Every so often I like to play a game I call “CEO of Google.” The idea of the game is that through some combination of weird circumstances, you are now the CEO of Google. Don’t wor…

My next project: AutoSEO

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

This was an April Fool’s joke. I’ve been working really hard with some friends on a project to handle SEO automatically. Now we’re ready to take the wraps off it over at seo.ninja. One of the ideas that helped the World Wide Web succeed was that it separated presentation and content. You could write your […]

Chronicling America: Historic American Newspapers: Topics in Chronicling America: "President Cleveland and Rumors of a Cancerous Growth"

by @ Chronicling America: Historic American Newspapers

During the summer of 1893 President Grover Cleveland informs reporters he is embarking upon a four-day cruise on a friend’s yacht to “do a little fishing.” But why is Dr. Joseph Bryant aboard? And what’s with the makeshift operating room they’ve installed? An innocent recreational cruise or does President Cleveland have a grave health issue to hide? Read more about it!

Chronicling America: Historic American Newspapers - 114 YEARS AGO: “In Heart of City,” The San Francisco Call, May 13, 1903

by @ Chronicling America: Historic American Newspapers

In the heart of San Francisco, CA, on May 12, 1903, President Theodore Roosevelt was greeted by throngs of spectators. The following day the San Francisco Call (San Francisco, CA) reported on the parade in detail, describing the military splendor, decorations on Market Street, bells pealing out and the roar of the crowd. In addition to coverage in historic newspapers, the Library of Congress also provides access to a rare early silent film of the parade, where you can see Roosevelt standing in his carriage and waving to the throngs… you can almost hear him say, as quoted in the Call, “This is magnificent.”….Read (and see!) more about it and follow us on Twitter @librarycongress #ChronAm!

Chronicling America: Historic American Newspapers: 100 Years Ago: “New 'Tanks' Are Things of Horror,” Harrisburg Telegraph, September 19, 1916

by @ Chronicling America: Historic American Newspapers

In September 1916, British military forces debut a new weapon of war on the battlefields of France – the "tank." One reporter describes the machines as "incredible as a nightmare or one of Jules Verne’s fantastic imaginings.” Read more about it!

Chronicling America: Historic American Newspapers: DID YOU KNOW? Dozens of African American newspapers are available in Chronicling America!

by @ Chronicling America: Historic American Newspapers

55 African American newspapers from across the US, are available online in #ChronAm. Included among these titles are issues of Frederick Douglass’ newspaper the New National Era. In his first issue, Douglass writes “It has been a cherished hope of mine, since the abolition of slavery, that…some new man…thoroughly alive to the great interests of our newly enfranchised people, would arise and establish here in the Capital of the nation  a large public journal, which should in some measure serve as a banner on the outer wall of our liberties…I believe the New National Era can be made such a journal…” #BlackHistoryMonth Read more about it and follow us on Twitter @librarycongress #ChronAm!  

 

Chronicling America: Historic American Newspapers: 97 Years Ago: "Westminster Dog Show Draws Record Entry," New-York Tribune, Feb. 8, 1920

by @ Chronicling America: Historic American Newspapers

That’s a lotta barks!  Judges line up as 1,612 canines make their way to Grand Central Palace for the Westminster Kennel Club’s exhibition.  For a full re-pawt of the 44th annual show, look no fur-ther than the New-York Tribune (New York, NY) issue for February 8, 1920. Read more about it and follow us on Twitter @librarycongress #ChronAm! 

Athens Messenger Newspaper Archives, Dec 26, 1946, p. 9

Athens Messenger Newspaper Archives, Dec 26, 1946, p. 9


NewspaperArchive.com

Read Athens Messenger Newspaper Archives, Dec 26, 1946, p. 9 with family history and genealogy records from Athens, Ohio 1850-2015.

Chronicling America: Historic American Newspapers: 227 Years Ago: "Fellow Citizens...," Gazette of the United-States, Jan. 9, 1790

by @ Chronicling America: Historic American Newspapers

On Jan. 8, 1790, beginning with "Fellow Citizens of the Senate and the House of Representatives, I embrace with great satisfaction the opportunity, which now presents itself, of congratulating you on the present favorable prospects of our public affairs...." President George Washington delivered the first State of the Union address to the joint session of Congress meeting in New York City, the U.S. capital at the time.... Read more about it and and follow us on Twitter @librarycongress #ChronAm!

 

Berkshire Hathaway

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

My taste in financial advice runs toward the simple and the lessons I’ve learned the hard way. But I still like reading about investing/finance, and I recently read through the 2014 annual report for Berkshire Hathaway. Given that it was the 50th anniversary of Warren Buffett taking charge of Berkshire, I have to admit that […]

Chronicling America: Historic American Newspapers: “The Evolution of Memorial Day“ (from the National Endowment for the Humanities)

by @ Chronicling America: Historic American Newspapers

Did you know that Memorial Day used to be known as Decoration Day?  Or that the practice of honoring the war dead during spring first arose in the South as the Civil War ended?  Featuring newspapers from around the country during the nineteenth and early twentieth centuries, discover more about the fascinating history of this holiday….Read more about it and follow us on Twitter @NEH_PresAccess and @librarycongress #ChronAm!

Chronicling America: Historic American Newspapers: 106 Years Ago: "Startling Feat Crowns Trip of Aviator Atwood," The Washington Herald, July 15, 1911

by @ Chronicling America: Historic American Newspapers

Attempting what only a handful of daredevil flyers would dream of, “birdman” Harry N. Atwood made a record-breaking 14-day multi-leg trip from Boston to Washington, DC,  at the helm of a Moth biplane. Several days after his arrival, "the biplane scudded and clipped over the Tidal Basin, its wings all a-quiver," as he landed on the White House grounds just in time for a luncheon held in his honor.  For the “strength of his exploits”, he was presented the gold medal of the Washington Aero Club by President Taft himself. Read more about the adventurous airman and follow us on Twitter @librarycongress #ChronAm!

 

Chronicling America: Historic American Newspapers: 114 Years Ago : "Pittsburg's Success in the Championship Series With Boston Depends On These Men," The Evening World, October 2, 1903

by @ Chronicling America: Historic American Newspapers

On October 1, 1903, the Boston Americans play the Pittsburgh Pirates in the 1st game of the modern World Series.  In the month before the game, a compromise known as the National Agreement resolved the conflict between the rival American and National Leagues and laid the foundation for the World Series that continues to this day. Check out this article for more and don't forget to follow us on Twitter @libraryofcongress #ChronAm!  

Chronicling America: Historic American Newspapers: 100 Years Ago: "Turkeyless Thanksgiving Menus," Perrsyburg Journal, Nov. 30, 1916

by @ Chronicling America: Historic American Newspapers

For non-meat eaters and the frugal, a century ago the Perrysburg Journal (Perrysburg, OH) shared suggestions for a feast of Thanksgiving dishes fit for the most discerning vegetarian palate. Including such delectables as Cream of Chestnut Soup, Vegetable Turkey (2 kinds!), and Nesselrode Pudding (a frozen custard dessert), the result is a choice menu for any celebration...  Read more about it!

 

Gene panel sequencing in Brazilian patients with retinitis pigmentosa

Gene panel sequencing in Brazilian patients with retinitis pigmentosa


International Journal of Retina and Vitreous

Retinal dystrophies constitute a group of diseases characterized by clinical variability and pronounced genetic heterogeneity. Retinitis pigmentosa is the most common subtype of hereditary retinal dystrophy and is characterized by a progressive loss of peripheral field vision (Tunnel Vision), eventual loss of central vision, and progressive night blindness. The characteristics of the fundus changes include bone-spicule formations, attenuated blood vessels, reduced and/or abnormal electroretinograms, changes in structure imaged by optical coherence tomography, and subjective changes in visual function. The different syndromic and nonsyndromic forms of retinal dystrophies can be attributed to mutations in more than 250 genes. Molecular diagnosis for patients with retinitis pigmentosa has been hampered by extreme genetic and clinical heterogeneity between retinitis pigmentosa and other forms of retinal dystrophies. Next generation sequencing (NGS) technologies are among the most promising techniques to identify pathogenic variations in retinal dystrophies. The purpose of this study was to discover the molecular diagnosis for Brazilian patients clinically diagnosed with a retinitis pigmentosa pattern of inheritance by using NGS technologies. Sixteen patients with the clinical diagnosis of retinitis pigmentosa were included in the study. Their DNA was sequenced in a panel with 132 genes related to retinal dystrophies using the Illumina® platform. Sequence analysis and variation calling was performed using Soft Genetics®, NextGene, and Geneticist Assistant software. The criteria for pathogenicity analysis were established according to the results of prediction programs (Polyphen 2, Mutation taster and MetaCore™) and comparison of pathogenic variations found with databases. The identified potentially pathogenic variations were all confirmed by Sanger sequencing. There were 89 variations predicted as pathogenic, but only 10 of them supported the conclusion of the molecular diagnosis. Five of the nine patients were autosomal dominant RP (56%), two (22%) were autosomal recessive RP, and two (22%) were X-linked RP. Nine of the 16 patients (56%) had probably positive or positive results. The Next Generation Sequencing used in this study allowed the molecular diagnosis to be confirmed in 56% of the patients and clarified the inheritance pattern of the patient’s retinal dystrophies.

Latest Updated Feeds: Fresh Baked Tech News

Latest Updated Feeds: Fresh Baked Tech News


Latest Updated Feeds: Fresh Baked Tech News

Fresh Founder Bakes Latest Updates, Exploring and Unfolding New Tech Feeds. Upcoming Gadgets with Reviews. Technology Leaks and Best Opinions.

Thanks, Amit

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

Amit Singhal just announced that he’s retiring toward the end of the month. Amit has been a formative part of Google’s search team, but he’s also a good friend. Last year, after he marked 15 years with Google, I wrote this about Amit’s contributions: Amit Singhal, one of the unsung heroes of Google, just celebrated […]

Fixing “full path disclosure” issues

by Matt Cutts @ Matt Cutts: Gadgets, Google, and SEO

Whether you’re running a web service or a blog, you should always keep your software fully patched to prevent attacks and minimize your attack surface. Another smart step is to prevent full path disclosures. For example, if your blog or service throws an error like “Warning: require(ABSPATHwp-includes/load.php) [function.require]: failed to open stream: No such file […]

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