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Annual Aboriginal Youth Achievement Awards

by admin @ Qalipu

The Congress of Aboriginal Peoples is currently seeking nominations for its Annual Aboriginal Youth Achievement Awards.  Recognizing youth for their achievements ...

How Do I Sell My IT Company?

by mitchellfrom @ Mitchell From

Sell my IT company? – Have you thought about this question? If you’re an owner of an I.T. (Information Technology) company, you’ve probably had that thought before.  How do I know?  I’ve been there.  I have spent over 15 years in the I.T. industry and that thought ran through my head plenty of times.  It’s […]

The post How Do I Sell My IT Company? appeared first on Mitchell From.

Five Nonprofit Marketing Strategies for Philanthropic Success

by Allie Schotanus @ UpCity

In addition to guest posting on the UpCity blog, Priority Marketing is featured as a Top Digital Marketing Agency in Fort Myers. Check out their profile here. Finding the most cost-effective way to reach the right people is particularly important to the non-profit sector. It’s part of the reason non-profit marketing is becoming increasingly digital-based. Here we cover five nonprofit […]

The post Five Nonprofit Marketing Strategies for Philanthropic Success appeared first on UpCity.

Build Your Email List Using Incentives

Build Your Email List Using Incentives

by Christina @ Michigan Marketer

Building a mailing list is a very important and potentially highly effective way to increase your reach and possibly your sales from a website. By having a mailing list on your site, you can gain direct access to your very most loyal fans and this will then mean you can promote your products [...]

The post Build Your Email List Using Incentives appeared first on Michigan Marketer.

plath's meats | Butcher in 2200 E Mitchell Rd - Petoskey MI - Reviews - Photos - Phone Number

plath's meats | Butcher in 2200 E Mitchell Rd - Petoskey MI - Reviews - Photos - Phone Number


BirdEye

7 reviews of plath's meats from Petoskey, MIBest bacon and hot dogs around

Top 25 Digital Marketing Articles – Week of 10/13/17

by Morgan Dowling @ UpCity

This week’s roundup, includes tips to create a data driven Email Marketing strategy, boost Conversions using any landing page, and optimize your website from a mobile SEO standpoint. Learn how to use text Emails in your Email Marketing strategy, and market your business using Social Media giveaways. We’ve covered all of this news and, much […]

The post Top 25 Digital Marketing Articles – Week of 10/13/17 appeared first on UpCity.

What is the quickest way to Fail at Networking?

by mitchellfrom @ Mitchell From

The quickest way to fail at networking is tied to the same reason that we came out and started networking in the first place.  We are typically introduced to networking through an individual, book, audio or video resource… encouraging us to grow our sales, our profits and our bottom line… through networking.  While this is […]

The post What is the quickest way to Fail at Networking? appeared first on Mitchell From.

New Band Council elected for Benoit 1st nation

by admin @ Qalipu

Benoit 1st Nation would like to announce that the following people have been nominated for the Band Council: Jasen Benwah aka ...

SEO Expert | Brand & Reputation Management | Ann Arbor, MI | Mitchell From

SEO Expert | Brand & Reputation Management | Ann Arbor, MI | Mitchell From


Mitchell From

Mitchell From’s company, Authority Solutions, has positioned themselves as the SEO Experts in Ann Arbor, MI and the surrounding areas of the state. Search Engine Optimization (SEO) is the process used to enhance the online visibility of your business and increase targeted web traffic in order to increase company income through working with highly trained, top of …

Does Your Hosting Account Matter?

by SEOteric User @ SEOteric

Your Website Developer Matters – Part 2 In Part 1 of Does Your Website Developer Matter, we talked about the process of building a website, some costs, and what really goes into making a successful website. An often overlooked part of websites is the hosting account. A hosting account acts as a host for the... CONTINUE READING

The post Does Your Hosting Account Matter? appeared first on SEOteric.

Silverwood Country Retreat – Weekend Getaway

by mitchellfrom @ Mitchell From

Silverwood Country Retreat (in Harris County & Waller County) was the resent destination for my wife’s and my “weekend getaway.”  We were introduced to the wonder family of the Timmermans and their property that they have opened to the public through some business connections.  As a side note, it’s amazing to me how networking is in […]

The post Silverwood Country Retreat – Weekend Getaway appeared first on Mitchell From.

Appreciating Lake St. Clair

by Penny Carroll @ Macomb County Chamber of Commerce

  Community leaders took to the lake on Wednesday, July 26, for the Macomb County Chamber’s ninth annual Lake St. Clair Appreciation Day. This invitation-only event was designed to educate and engage lawmakers, area business leaders and other interested parties on Lake St. Clair’s vitality and impact as a tourism destination, lifestyle epicenter and economic […]

The post Appreciating Lake St. Clair appeared first on Macomb County Chamber of Commerce.

Lockheed Martin visits Macomb County to connect with potential suppliers

by Penny Carroll @ Macomb County Chamber of Commerce

  Macomb County welcomed a team of representatives from Lockheed Martin for an invitation-only matchmaking event today. Headquartered in Bethesda, Maryland, Lockheed Martin is a global security and aerospace company that employs approximately 97,000 people worldwide and is principally engaged in the research, design, development, manufacture, integration and sustainment of advanced technology systems, products and […]

The post Lockheed Martin visits Macomb County to connect with potential suppliers appeared first on Macomb County Chamber of Commerce.

Converting More Customers With Better Funneling

by SEOteric User @ SEOteric

Increase Website Conversions with Featured Content One of the best ways to capture the attention of your website visitors is to quickly show them what they are looking for. When a website visitor visits your website, you have just a few seconds to capture their attention. During that brief first impression period, they have to... CONTINUE READING

The post Converting More Customers With Better Funneling appeared first on SEOteric.

5 Tips to Successful Hyperlocal Marketing

by admin @ Solutio

Hyperlocal Marketing When it comes to the concept of hyperlocal marketing, many people don’t know how to classify it. Is the idea just a flash-in-the-pan notion, or does the phrase truly represent a forthcoming trend in digital marketing that will change the way you spread...

The post 5 Tips to Successful Hyperlocal Marketing appeared first on Solutio.

5 CYBER SECURITY THREATS TO BE AWARE OF NOW!

by Samantha @ Web & Moore, Inc

Spring time has already begun and there’s no better time than now to protect yourselves from the innovative and imminent cyber threats of 2017. Learn more about some of the biggest cyber threats to look out for in the upcoming year. 1. Ransomware Attacks Ransomware has been a tremendous threat...

How to Map Your Content across the Experience Journey

by ContentOro @ ContentOro

In last week’s blog, Where is the Content Engine Heading?, we started to talk about developing a Content Experience Strategy. We continue here with how to use content mapping to match where your customer is in their journey. As we conduct an audit of our existing assets and add new content to the mix, it
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The post How to Map Your Content across the Experience Journey appeared first on ContentOro.

Mitchell From Speaking @ Lone Star College – Tomball on 3/21/12

by mitchellfrom @ Mitchell From

Small Business Success Seminars A Special Thanks to Karen Cavallaro for inviting me back to speak for the college.  This year she brings the Business Success Seminar Series to Tomball.  I am honored to be asked to speak at Tomball, since it’s where I live.  I look forward to sharing some tips on networking, as […]

The post Mitchell From Speaking @ Lone Star College – Tomball on 3/21/12 appeared first on Mitchell From.

Digital Marketing Services in Athens & Atlanta - SEO and Website Design

Digital Marketing Services in Athens & Atlanta - SEO and Website Design


SEOteric

SEOteric is a digital marketing agency specializing in web design and SEO with locations in Athens and Atlanta, GA serving clients across the USA.

Free SEO Analysis - U2Them

Free SEO Analysis - U2Them


U2Them

Best Local SEO Company specializing in Search Engine Optimization, NAP Duplicate Suppression and Reputation Management for companies

Leelanau.com

Leelanau.com


Leelanau.com

Leelanau County, Michigan on the Internet

Social Media: Stats You Might Not Know

by ContentOro @ ContentOro

Looking for Connection, Information, and Fun? Two types of entities comprise social media: social networks and social communities. A network is the social structure made up of people connected to an individual. Each of us has our own social network that includes our family, friends, work colleagues, classmates, neighbors, and more; we are the glue
+ Read More

The post Social Media: Stats You Might Not Know appeared first on ContentOro.

Preparing to Sell SEO to Small Businesses

by Pete Rufo @ UpCity

Whether you’re an established business who has decided to start offering SEO services or you’ve just decided to branch off on your own and start an agency, selling SEO is harder now that it has ever been. Just like in anything else you do for your business, you have to prepare and selling SEO, in particular, […]

The post Preparing to Sell SEO to Small Businesses appeared first on UpCity.

Carry your drink in your left hand, when networking

by mitchellfrom @ Mitchell From

With Christmas and New Years coming fast, we will have plenty of networking opportunities that will have drinks of all kinds, available.  This is always welcomed, especially because of all the talking that we do while networking.  Now, whether you think that toting a drink around the room makes you look more sophisticated or whether […]

The post Carry your drink in your left hand, when networking appeared first on Mitchell From.

Federal - State Representatives * Macomb County Chamber of Commerce

Federal - State Representatives * Macomb County Chamber of Commerce


Macomb County Chamber of Commerce

  U.S.REPRESENTATIVES OF MACOMB COUNTY 10th Congressional District Paul Mitchell (R) 48701 Van Dyke Avenue, Shelby Township, MI 48317 Phone: (586) 997-5010; Fax: (586) 997-5013 211 Cannon Building, Washington, DC 20515 Phone: 202-225-2106; Fax: 202-226-1169 Website:  mitchell.house.gov/contact/offices Office hours: Monday -Friday 9:00 a.m. – 5:00 p.m. 9th Congressional District Sander Levin (D) 27085 Gratiot, Roseville, MI 48066 …

Happy Holidays!

by Samantha @ Web & Moore, Inc

The Web & Moore team would like to wish everyone a very Happy Holiday! I wanted to take a few minutes out of my day and personally thank you for your business. It means a lot to us here at Web & Moore and we certainly look forward to all the new...

Macomb County Chamber welcomes new members

by Penny Carroll @ Macomb County Chamber of Commerce

  The Macomb County Chamber welcomed the following businesses to its membership in May 2017: Martha T. Berry Medical Care Facility, Mount Clemens Meadows Assisted Living and Care Campus, Novi Trion Solutions, Inc., Troy Great Lakes Ace Hardware – 11 Stores, Metro Detroit Area Kroger –  20 Stores, Metro Detroit Area Kroger Michigan Division Office, […]

The post Macomb County Chamber welcomes new members appeared first on Macomb County Chamber of Commerce.

Here Kitty Kitty: Fantastic Northport Bobcat Photo

by leelanau.com @ Leelanau.com

Here Kitty Kitty by Scot Wack Scot Wack of Northport caught an incredible photo of this bobcat just 20 feet from his house! The University of Michigan’s Animal Diversity Web’s entry for Lynx rufus, the bobcat says (in part): Bobcats can be found in a variety of habitats, including forests, semi-deserts, mountains, and brushland. They […]


Here Kitty Kitty: Fantastic Northport Bobcat Photo was first posted on October 13, 2017 at 7:45 am.
©2015 "Leelanau.com". Use of this feed is for personal non-commercial use only. If you are not reading this article in your feed reader, then the site is guilty of copyright infringement. Please contact me at lci@leelanau.com

Google Getting It Right

by SEOteric User @ SEOteric

Google has been rolling out updates and changes for a while now, and every time there is a “significant” update, the web stirs up with analysis and break downs on what the changes are, who got penalized, and what percentage of websites are affected. These changes really affect the SEO industry as a whole and... CONTINUE READING

The post Google Getting It Right appeared first on SEOteric.

How to be a Graphic Designer – Part 4

by Whitney @ Learning Designs, Inc.

What are the basics I need to know to be a graphic designer? Proximity As demonstrated in How to be a  Graphic Designer Part 3: Balance, we learned about the importance of the placement and arrangement of objects on a page. Now we will learn...

The post How to be a Graphic Designer – Part 4 appeared first on Learning Designs, Inc..

Testimonials | Website Design & SEO | Web & Moore, Inc

Testimonials | Website Design & SEO | Web & Moore, Inc


Web & Moore, Inc. Custom Website Design & Development

Testimonials WebnMoore - custom website design, ecommerce development, graphic design, logos, internet marketing, seo, mobile websites, and more.

Demographic Research: 5 Free Resources to Find Your Audience

by Kiyo Wiesnoski @ UpCity

In addition to guest posting on the UpCity blog, Adlava is featured as a Top Web Designer in Las Vegas. Check out their profile here. While there are many great premium data brokers that provide detailed insights on demographics and behavior, not all of these resources are accessible to small or mid-size companies with smaller budgets. Sure, the AdWords Keyword Planner […]

The post Demographic Research: 5 Free Resources to Find Your Audience appeared first on UpCity.

The Lost Art of Personal Thank You’s

by mitchellfrom @ Mitchell From

The Lost Art of the Thank You Note  – Give Honest Sincere Appreciation I have learned a lot from Dale Carnegie during my life. As we start the new year off, I wanted to share a nugget that I have found very important. Writing a sincere thank you note is one of the professional skills […]

The post The Lost Art of Personal Thank You’s appeared first on Mitchell From.

See Our Article On SEOmoz!

by SEOteric User @ SEOteric

Check out our article on www.seomoz.org!  http://www.seomoz.org/ugc/its-getting-harder-and-harder-to-keep-a-white-hat-clean. We did a write up about blog comments and spam SEO tactics. We will do a follow-up on our site from info gathered from the comments on SEOmoz. Stay Tuned!

The post See Our Article On SEOmoz! appeared first on SEOteric.

Need a Lyft? Lyft is area’s first ride-sharing service

by leelanau.com @ Leelanau.com

Need a Lyft? The Traverse City Ticker reports that the ride-sharing service Lyft has launched in northern Michigan: …As with Uber, Lyft allows users to hail a ride through the service’s smartphone app. After plugging in their location and destination, users can request a ride, be matched with a Lyft driver in the vicinity, see an estimated […]


Need a Lyft? Lyft is area’s first ride-sharing service was first posted on September 25, 2017 at 8:45 am.
©2015 "Leelanau.com". Use of this feed is for personal non-commercial use only. If you are not reading this article in your feed reader, then the site is guilty of copyright infringement. Please contact me at lci@leelanau.com

Looking for the Best Treatment for Bleeding Gums?

by mitchellfrom @ Mitchell From

When it comes to finding the best treatment for bleeding gums, you really need to seek out a professional. I, myself, had some issues years ago. I actually was not a big proponent of getting in the dentist’s chair and over the years I grew a healthy fear of going to the dentist. As long […]

The post Looking for the Best Treatment for Bleeding Gums? appeared first on Mitchell From.

Carry your plate in your right hand!

by mitchellfrom @ Mitchell From

As we attend networking opportunities, we find that most of them revolve around food and drink.  It is true that food brings people together.  Just think back to the last few social gatherings at your house and ask yourself, where does everyone congregate?  In the kitchen!  We are so accustomed and comfortable with socializing around […]

The post Carry your plate in your right hand! appeared first on Mitchell From.

Is Your Business Prepared for Micro-Moments?

by admin @ Solutio

You no longer live in the moment. Face it—you live in micro-moments:

When your washer is beyond repair, a quick search tells you the pros and cons of top vs. front-loading machines. When you want to know, information is at your fingertip.
When you need caffeine out-of-town, a “nearest” search satisfies your craving. When you’re on the go, your mobile phone points the way.
When the printed instructions are lacking, you find your pick of videos in the blink of an eye. When you need “do” to be “done,” a video clip shows you how.
When you’re standing in the aisle debating which one to buy, the answer appears in a split second. When you’re ready to buy, your phone tells you which is “best.”
If that’s how you live your life, what does it mean for running your business? Is your business prepared for micro-moments?

The post Is Your Business Prepared for Micro-Moments? appeared first on Solutio.

Marketing Automation: How to Tie Marketing Activities to Sales Performance

by ContentOro @ ContentOro

Maximize Revenue Performance with Marketing Automation Marketing automation is increasingly being referred to as revenue-performance management technology because of how it positively impacts companies’ revenue. By capturing and nurturing leads and continually engaging customers in meaningful ways, marketing automation maximizes our revenue as potential prospects or customers no longer fall through the cracks. By providing
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The post Marketing Automation: How to Tie Marketing Activities to Sales Performance appeared first on ContentOro.

Resources for Marketers and Entrepreneurs - Michigan Marketer

Resources for Marketers and Entrepreneurs - Michigan Marketer


Michigan Marketer

Browse our list of Michigan business and submit your own. Find a networking or learning event near you. Resources and education for marketers and entrepreneurs. The best articles and insights to help market your Michigan business. Marketing Articles

Can Someone Please Explain Bounce Rate?

by SEOteric User @ SEOteric

One of the most common questions we get when looking at Google Analytics data is “What is Bounce Rate?“. Bounce rate is a tricky little metric that can be deceiving at first glance. Let’s go ahead and define a “Bounce” as “when a web site visitor only views a single page on a website, that... CONTINUE READING

The post Can Someone Please Explain Bounce Rate? appeared first on SEOteric.

Leland Public School Farmers Market this Tuesday, Oct 10th

by leelanau.com @ Leelanau.com

October is a wonderful time at Leelanau’s local farmers markets. To give students a chance to learn about the deliciousness of local food and importance of farming, he 11th annual  Leland School Farmers Market takes place tomorrow (Tuesday, October 10th) from 8:30 am – 12:30 pm in the Leland high school gym. This is a fantastic […]


Leland Public School Farmers Market this Tuesday, Oct 10th was first posted on October 9, 2017 at 8:52 am.
©2015 "Leelanau.com". Use of this feed is for personal non-commercial use only. If you are not reading this article in your feed reader, then the site is guilty of copyright infringement. Please contact me at lci@leelanau.com

Functional analysis of three BrMYB28 transcription factors controlling the biosynthesis of glucosinolates in Brassica rapa

Functional analysis of three BrMYB28 transcription factors controlling the biosynthesis of glucosinolates in Brassica rapa


SpringerLink

Glucosinolates (GSLs) are secondary metabolites that have anticarcinogenic activity and play defense roles in plants of the Brassicaceae family. MYB28 is known as a transcription factor that regulates

3 Conversion Rate Optimization Techniques for Field Service Businesses

by Josh Astete @ UpCity

In addition to guest posting on the UpCity blog, Web Full Circle is featured as a Top Marketing Consultant in Charlotte. Check out their profile here. For a long time, field service businesses have relied primarily on traditional marketing tactics. However, most field service businesses are realizing the importance of having a strong online presence and are making a foray into […]

The post 3 Conversion Rate Optimization Techniques for Field Service Businesses appeared first on UpCity.

Get Digital Marketing Solutions & Accelerate Your Business in Mid-Michigan

by admin @ Solutio

Find the Right Digital Marketing Provider Have you ran the gamut of digital marketing providers in mid-Michigan without any luck in finding a company that can fit your specific needs? Have you researched site after site, hoping for some sort of clarity concerning a tech-savvy...

The post Get Digital Marketing Solutions & Accelerate Your Business in Mid-Michigan appeared first on Solutio.

Does It Matter Who Builds Your Website?

by SEOteric User @ SEOteric

Your Website Developer Matters – Part 1 You need a website, but aren’t sure what direction to go. You see commercials about $199 websites, getting a website for $9.99 a month, and then see companies charging thousands of dollars for websites.  Is there a difference in these services, and which one is right for you?... CONTINUE READING

The post Does It Matter Who Builds Your Website? appeared first on SEOteric.

Macomb County Chamber welcomes new members in March

by Penny Carroll @ Macomb County Chamber of Commerce

  The Macomb County Chamber welcomed the following businesses to its membership in March 2017: • Caliber Home Loans, Sterling Heights • Michael Agnello Jewelers, St. Clair Shores • Alexandria Party & Cafe Grill, Fraser • Hoover Electric Plumbing Heating Cooling, Clinton Twp • Cass Collision, Shelby Twp • Chesterfield Township Library, Chesterfield Twp • […]

The post Macomb County Chamber welcomes new members in March appeared first on Macomb County Chamber of Commerce.

The Benefits of Claiming Your Google My Business Listing

by admin @ Solutio

Short and sweet, a Google My Business listing can be a significant part of your presence on the web. When customers are searching for a product or service, Google My Business provides the directional arrow to you. The benefits of claiming your Google My Business listing are many, and it would be more than a missed opportunity not to claim it and actively manage it.

The post The Benefits of Claiming Your Google My Business Listing appeared first on Solutio.

Do Social Signals Affect SEO?

Do Social Signals Affect SEO?


Vivial

LocalVox asked marketing experts & actual small businesses to share their opinions on how social signals affect SEO (or don't). Keep reading to find out how

Agency Playbook: Overcoming Common Barriers in the Pitch Process

by Jordan Stella @ UpCity

It’s no secret that digital marketing has evolved into an absolute necessity for businesses large and small. Spending on digital advertising continues to grow year after year at an unstoppable rate. In fact, spending on digital is expected to reach more than $110 billion by 2020. Companies are increasingly turning to digital as their main vehicle […]

The post Agency Playbook: Overcoming Common Barriers in the Pitch Process appeared first on UpCity.

Top 25 Digital Marketing Articles – Week of 10/06/17

by Morgan Dowling @ UpCity

This week’s roundup, includes tips to create an effective Email Marketing strategy, make your content more engaging, and influence customer engagement with SEO. Learn how to use your CRM software in the right manner, and create a Social Media plan. We’ve covered all of this news and, much more, below! From the UpCity Blog: Entermotion […]

The post Top 25 Digital Marketing Articles – Week of 10/06/17 appeared first on UpCity.

Sonya Aston on – “Are Elections Confusing You?”

by mitchellfrom @ Mitchell From

Value Giving, Blog Contributor – Sonya Aston I have asked some people that I Know, Like & Trust… to provide guest articles that bring needed “value” to the general public.  This is where they begin, with Sonya Aston… who happens to be running for the 127th State District Court Republican Judge.  Well, here’s the good […]

The post Sonya Aston on – “Are Elections Confusing You?” appeared first on Mitchell From.

Chamber of Commerce joins ‘Good Jobs for Michigan’ effort

by Penny Carroll @ Macomb County Chamber of Commerce

  The Macomb County Chamber of Commerce and its hundreds of members throughout the county today threw their support behind the Good Jobs for Michigan coalition and legislation designed to grow more good-paying jobs statewide and not be left on the sidelines behind other states like Indiana, Ohio, Kentucky and South Carolina. “We can’t avoid […]

The post Chamber of Commerce joins ‘Good Jobs for Michigan’ effort appeared first on Macomb County Chamber of Commerce.

Will Your Marketing Content Work…and Who Will Create It?

by ContentOro @ ContentOro

In last week’s blog, How to Map Your Content Across the Experience Journey, we talked about bringing the right marketing content to the right people at the right time in their customer journey. Today, we make sure that your marketing content is bringing all those benefits you’ve been promised. We’ll ask questions and provide answers,
+ Read More

The post Will Your Marketing Content Work…and Who Will Create It? appeared first on ContentOro.

Networking Diet – Are you on one?

by mitchellfrom @ Mitchell From

We’re going to talk about the “Networking Diet,” but I have to set things up for you first… Have you ever felt like you needed to lose a few pounds so you went on a diet? That’s not the issue. The issue, is when you constantly feel like you need to lose some weight. Why? […]

The post Networking Diet – Are you on one? appeared first on Mitchell From.

What is Local Search Engine Optimization & Citations?

by Samantha @ Web & Moore, Inc

Local Search Engine Optimization For local business owners, it is important to understand why you need to combine BOTH Geotargeting/Citations and Organic Local SEO, in order to get ahead of the competition. People are LOCAL! They shop local, eat local, and live local. No matter how big the world is,...

Our Office has MOVED!

by Samantha @ Web & Moore, Inc

We have moved our office to a NEW location! Our headquarters is now located in Brighton, Michigan!   Find us on the map! Still servicing the entire Nation! Clients in all 50 States and International!

16/03/2017, A' Mire ri Mòir - BBC Radio nan Gàidheal

16/03/2017, A' Mire ri Mòir - BBC Radio nan Gàidheal


BBC

Tha Mairead NicIllinnein anns a' chathair an-diugh a' toirt thugaibh taghadh ciùil.

Xiu Xiu - Tickets - El Club - Detroit, MI - March 30th, 2017

Xiu Xiu - Tickets - El Club - Detroit, MI - March 30th, 2017


El Club

FORGET was recorded during a period of epic productivity for Xiu Xiu. While writing FORGET, they released the lauded Plays the Music of Twin Peaks, collaborated with Mitski on a song for an upcoming J

North Bar Lake in the Sleeping Bear Dunes National Lakeshore

by leelanau.com @ Leelanau.com

North Bar Lake by Mark Smith The Sleeping Bear Dunes National Lakeshore’s North Bar Lake page says: North Bar Lake is one of the most popular beaches in the Lakeshore because it has shallow, clear water over a sandy bottom makes for warmer swim than in Lake Michigan. But for those who like the refreshing cool […]


North Bar Lake in the Sleeping Bear Dunes National Lakeshore was first posted on October 7, 2017 at 1:03 pm.
©2015 "Leelanau.com". Use of this feed is for personal non-commercial use only. If you are not reading this article in your feed reader, then the site is guilty of copyright infringement. Please contact me at lci@leelanau.com

Avoid Tech Support Phone Scams

by 48078 @ Spec Tec Computers

Over the last two years I’ve done computer service in Cadillac, MI to remove the damages done by tech support phone scams. They are very elaborate in how they trick individuals into handing them their credit cards. It’s very important that people become aware of how to recognize tech based fraud. Doing so can prevent [...]

Rutgers recruiting class of 2017: Individual first impressions

Rutgers recruiting class of 2017: Individual first impressions


On the Banks

The SVP of my department always leaves us with "one thing" so here’s something for each commit.

Dedicated vs Shared Hosting

by Samantha @ Web & Moore, Inc

Web & Moore has a Dedicated Server for hosting…why is that better than shared? On Shared Servers Your Sharing Same IP… Having the same IP address in shared hosting is the main concern when other sites in the server is actually being blacklisted for unethical activities such as spamming or...

Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia

Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia


Molecular Brain

Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that are sharply increasing in prevalence worldwide. Intriguingly, ASD is often accompanied by an array of systemic aberrations including (1) increased serotonin, (2) various modes of gastrointestinal disorders, and (3) inflammatory bowel disease (IBD), albeit the underlying cause for such comorbidities remains uncertain. Also, accumulating number of studies report that the gut microbial composition is significantly altered in children with ASD or patients with IBD. Surprisingly, when we analyzed the gut microbiota of poly I:C and VPA-induced mouse models of ASD, we found a distinct pattern of microbial dysbiosis that highly recapitulated those reported in clinical cases of ASD and IBD. Moreover, we report that such microbial dysbiosis led to notable perturbations in microbial metabolic pathways that are known to negatively affect the host, especially with regards to the pathogenesis of ASD and IBD. Lastly, we found that serum level of serotonin is significantly increased in both poly I:C and VPA mice, and that it correlates with increases of a bacterial genus and a metabolic pathway that are implicated in stimulation of host serotonin production. Our results using animal model identify prenatal environmental risk factors of autism as possible causative agents of IBD-related gut microbial dysbiosis in ASD, and suggest a multifaceted role of gut microbiota in the systemic pathogenesis of ASD and hyperserotonemia.

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